\n\nMethods: 106 non-obese Japanese patients with type
2 diabetes were recruited for the measurement of GFR, TNF, HMW adiponectin, leptin, hsCRP and some variables including urinary albumin. BMI, serum creatinine, and urinary albumin levels were 22.2 +/- 0.2 kg/m(2) (17.1-24.9 kg/m(2)), 0.76 +/- 0.02 mg/dl (0.39-1.38 mg/dl), 40.4 +/- 4.3 mg/gCr (1.6-195.0 mg/gCr), respectively. They were stratified into two groups based on the value of eGFR: low eGFR (eGFR <60 ml/min/1.73 m(2)) and normal eGFR (eGFR >60 ml/min/1.73 m(2)). Logistic regression analysis was used for statistical analysis.\n\nResults: Whereas univariate logistic regression analysis showed that gender, diabetes duration, triglyceride, PI3K inhibitor review HDL Mizoribine cholesterol, uric acid, urinary albumin, and soluble TNF receptors (sTNF-R1, sTNF-R2) are associated with the development of stage 3 CKD, multivariate logistic regression analysis revealed that sTNF-R2 (Odds ratio 1.003, 95% confidence interval 1.000 to 1.005, P = 0.030) showed significant associations with the development of stage 3 CKD.\n\nConclusions: Circulating TNF receptor 2 is an independent
risk factor for CKD in non-obese Japanese patients with type 2 diabetes. (C) 2013 Published by Elsevier Ireland Ltd.”
“Background. One of the genome-wide linkage studies performed in migraine has yielded a significant linkage of migraine (with and without aura) with markers located at 6p12.2-21.1. This locus (named MIGR3) has not been replicated in the only genome-wide association scan study performed to date or in previous genome-wide linkage studies.\n\nObjective.-Our objective had been to replicate the MIGR3 locus performing a family-based association study.\n\nMethods.-A sample of 594 subjects belonging to 134 migraine families of diverse complexity underwent genotyping for the markers previously published as linked at 6p12.2-21.1 migraine locus. Family-based
association test, under different models of inheritance, and also the model-free TDT analysis were MEK162 chemical structure performed.\n\nResults.-The best result was obtained with the D6S1650 marker under the additive model (rank [ S observed] = 265.0; permuted P =.0006), using family-based association test program (HBAT subprogram). Similar results were obtained with the model-free TDTPHASE algorithm (P <.0001, corrected). Nominal significant P values were obtained for D6S1630, D6S452, and D6S257. After correction for multiple testing with the stratified false-discovery rate, all markers showed significant association (P <.0001).\n\nConclusion.-We corroborated that the MIGR3 locus at 6p12 is a genetic risk for migraine with and without aura.”
“Purpose: To evaluate the incidence of coexistent peripheral vestibular dysfunction and cardiovascular autonomic dysfunction in patients undergoing evaluation for dizziness exacerbated by postural changes.