Of note, minor variation was observed in the IFN-λ3 CC frequency between the two study cohorts with prevalence in CHARIOT and PREDICT being 34.8% and 30.7%, respectively. The prevalence of IFN-λ3 CC among other ethnic groups was 80% in click here Asians (n = 111), 33% in Aboriginals (n = 33), 18% in self-reported Mediterranean subjects (n = 32), 77% in Maori and Pacific Islanders (n = 17), 46% in Middle Easterners (n = 13), and 40% in Hispanics (n = 10). Compared with Caucasians, the frequency of IFN-λ3 CC was significantly higher among Asians (P < 0.0001) and Maori/Pacific Islander subjects (P < 0.0001) (Fig. 1a).
The overall prevalence of the good-responder IFN-λ3 rs8099917 TT genotype among self-identified Caucasians was 52% (n = 1399), with the prevalence in the CHARIOT and PREDICT cohorts being 55% and 52%, respectively. Among other ethnic groups, the overall prevalence of the IFN-λ3 rs8099917 TT genotype was 86% in Asians (n = 108), 63% in Aboriginals (n = 32), 88% in Maori/Pacific Islanders find more (n = 17), 29% in self-reported Mediterraneans (n = 31), 54% in Middle Easterners (n = 13), and 67% in Hispanics (n = 9) (Fig. 1b). The
prevalence of IFN-λ3 rs8099917 TT genotype was significantly higher in Asians (P < 0.0001) and Maori/Pacific Islanders (P < 0.005) compared with Caucasians. A total of 1642 subjects were tested for both the IFN-λ3 rs12979860 and rs8099917 SNPs. The frequency distribution of the combination the two IFN-λ3 genotypes in the overall cohort, Caucasians, Aboriginals, and Asians is shown in Table 4. Overall, 846 subjects were heterozygote carriers
of the IFN-λ3 rs12979860 nonresponder T allele. Of these, 281 (33%) carried the responder rs8099917 TT genotype. Among Caucasians, the overall prevalence of the combined IFN-λ3 rs12979860 CT and rs8099917 TT genotype was 18%, while in Aboriginals and Asians, it was 29% and 6.5%, respectively. This national, multicenter, observational study is the largest yet to report the distribution of IFN-λ3 polymorphisms in treatment-naïve HCV Gt1-infected subjects. The study population included subjects from two large separate Methane monooxygenase studies conducted within Australia. The larger of these, the PREDICT study, was a prospective observational study conducted by the ALA CRN in a real-life setting of liver and hepatitis clinic sites. The CHARIOT study was a large multicenter randomized, controlled trial of induction versus standard dose PEG-IFN and RBV in previously untreated HCV Gt1-infected patients. Both studies reflected the typical CHC population within Australia with patients recruited from up to 40 metropolitan and regional hepatitis treatment sites across all Australian States. This is in contrast with the initial GWAS from Australia that reported on IFN-λ3 polymorphisms in a cohort of patients recruited from a few select specialist centers.