Adjunctive therapy with hyperbaric oxygen was administered in two patients. In one patient a polyvalent clostridial antitoxin was administered . However, to our knowledge no commercially available polyvalent
clostridial antitoxin exists in Europe and in the US. Skin grafting to cover affected areas was required in three cases. Surgical complications PLX3397 cost included a case of erosion of the femoral artery treated with vascular grafting, severe bleeding of the groin area that was managed with ligation of profunda femoris artery and its branches. The most serious systemic complications of the infection were respiratory failure, renal failure, sepsis and resultant multiorgan failure. Notably, one patient who developed respiratory failure was receiving intramuscular pentazocin, an opioid analgesic for chronic pancreatitis associated pain. Pentazocin is not indicated for patients with pancreatitis and can itself depress critically the
respiratory function [4, 8]. Hospitalization ranged variably between 16 and 126 days and was relatively longer in patients with serious systemic complications of the disease. Functional status of the salvaged limb was reported in eight cases, five of them regaining normal function of the affected limb. Discussion Gas gangrene of the limbs is a rare infection due to anaerobe bacteria associated with high morbidity and mortality. Amputation is usually necessary to control infection and save life whereas
functional limb preservation is rare . Intravenous Pyruvate dehydrogenase drug users are considered at high risk for gas gangrene and it has been shown that Clostridia find more are able to survive in heroin preparations being mixed with citric acid and heated . Moreover, repeating trauma of soft tissue resulting from peculiar practices among illicit drug users, as the intramuscular injections with normal saline in our case, introduce organisms directly into deep tissue and create an anaerobic environment that is ideal for the proliferation of Clostridia. Such anaerobic environment also results from crash type injury, contaminated open fractures and retained foreign material and is associated with C.perfrigens gas gangrene [3, 5, 7, 9]. Spontaneous gas gangrene of the limbs is due to C. septicum in the vast majority of cases. C. septicum translocates from the gut suffering from a benign or malignant disease and causes metastatic infection [1, 10–12]. Incubation time is short usually less than 24 hours and the physical finding of crepitus is characteristic finding in the setting of soft tissue infection [5, 7, 10–12]. The sudden onset of pain, rapidly progressive soft tissue infection, development of blisters containing foul smelling brownish liquid with gas bubbles, soft tissue induration and discoloration may also be present [7, 10]. Plan X-rays identify gas in deep tissues and CT or MRI may assess spreading of infection along fascial planes.