An alteration in the Treg cell population might correspond
to the diminishment of the tumour mass in patients with cancer and could therefore be a useful marker of the intensity of the selective suppression of the host immune system and also of the degree of radicalism of a procedure. Certainly, it is well known that in order for anti-cancer therapy to succeed the proper immune response against cancer cells must be restored. Furthermore, monitoring the level of selective immune system suppression during cancer therapy might yield information that would support a decision to supplement standard therapy by immunotherapy or to increase the degree of radicalism of the applied therapy. Method of study We examined the Treg cell populations in the peripheral blood of a group of patients treated surgically for ovarian cancer. In each patient, Selleckchem HSP inhibitor the peripheral blood samples were collected both prior to and 1 day after the surgical procedure, and then again 5 days after the procedure. The presence of regulatory T cells in the samples was analyzed by means of flow cytometry. Results In our study, the percentages of FOXP3+ cells in the subpopulation of CD4+ T lymphocytes found in the peripheral blood of the patients before the surgical intervention were statistically
significantly higher than those observed in the peripheral blood of these same patients after the surgical procedure. Conclusion It would seem that the alteration in the Treg cell SAR245409 mouse subpopulation could be a key factor in determining the status of the tumour microenvironment. Most likely, it could provide information about whether the proper level of anti-cancer immune response could be restored. The possibility of restoring the immune response may directly correspond to the degree of radicalism of the surgical intervention. ”
“Like many other complex human disorders of unknown aetiology, autoimmune-mediated type 1 diabetes may Quinapyramine ultimately be controlled via a therapeutic approach that combines multiple agents, each with differing modes of action. The numerous advantages of such a strategy include the ability to minimize toxicities
and realize synergies to enhance and prolong efficacy. The recognition that combinations might offer far-reaching benefits, at a time when few single agents have yet proved themselves in well-powered trials, represents a significant challenge to our ability to conceive and implement rational treatment designs. As a first step in this process, the Immune Tolerance Network, in collaboration with the Juvenile Diabetes Research Foundation, convened a Type 1 Diabetes Combination Therapy Assessment Group, the recommendations of which are discussed in this Perspective paper. Type 1 diabetes (T1D), one of the most common autoimmune diseases, results from the progressive destruction of insulin-producing pancreatic β cells by CD4+ and CD8+ T cells.